Description
Sal-like protein 4 (SALL4) is a zinc-finger transcription factor that serves as a master regulator of embryonic pluripotency and is involved in processes associated with stem cell activities. SALL4 expression in germ cells makes it a useful marker for germ cell tumors such as seminoma, embryonal carcinoma, yolk sac tumors and teratomas. SALL4 expression is also seen in the spermatogonia of normal testis.
Additional information
| Catalog No. | Mob591 Concentrated, PDM591 Prediluted |
|---|---|
| Clone | 6E3 |
| Isotype | IgG1 |
| Immunogen | SALL4 (partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa |
| Species | Mouse |
| Cellular Localization | Nuclear |
| Positive Control Tissue | Seminoma |
| Pretreatment | EDTA Buffer pH 8.0 |
| Incubation & Temperature | 30 min @ RT |
| Intended Use | IVD |
| Detection System | PolyVue Plus – Two Step Detection System or Montage PolyVue Plus Auto Detection System for Montage 360 System |
| Description/Type | Mouse Monoclonal Antibody |
| Format | This product is supplied as a This product is supplied as a tissue culture supernatant and contains sodium azide as a preservative. and contains sodium azide as a preservative. |
DATASHEETS & SDS
DATASHEETS & SDS
| Download Datasheet |
| Download SDS Sheet – OSHA |
REFERENCES
REFERENCES
- Miettinen M, et al. SALL4 expression in germ cell and non-germ cell tumors: a systematic immunohistochemical study of 3215 cases. Am J Surg Pathol. 2014; 38:410-20. 2.
- Yang J, et al. Genome-wide analysis reveals Sall4 to be a major regulator of pluripotency in murine-embryonic stem cells. PNAS. 2008; 105:19756- 61.
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